CONP Portal | Dataset


Brainstem cholinergic-deficient mouse model dataset
Creators: Dr. Marco Prado
Contact: Marco Prado, mprado@robarts.ca
Licenses: CC0
Version: 1
Formats: CSV
Size: 5.0 MB
No of Files: 12
No of Subjects: 53
Primary Publication: Selective decrease of cholinergic signaling from pedunculopontine and laterodorsal tegmental nuclei has little impact on cognition but markedly increases susceptibility to stress. Helena Janickova et al. the Journal of the Federation American Societies for Experimental Biology (FASEB). https://doi.org/10.1096/fj.201802108R
Metadata file: DATS.json
Is About: Mus musculus
Other Dates: This Dataset Was Published In June 2019 In The Journal Of Federation Of American Societies For Experimental Biology : 2019-06-29 00:00:00
Description:
Male mice and their wild-type controls were evaluated at 7-10 months of age using the 5-Choice Serial Reaction Time (5-CSRT) task to assess attention. Immediately after (approximately at 9-12 months of age) these same mice were evaluated using the Extinction task to assess their ability to extinguish a response. A different cohort of male mice and their wild-type controls were evaluated at 11-13 months of age in the Pairwise visual discrimination (PVD) task to assess discrimination and reversal learning. Immediately after (still within 11-13 months of age) these same mice were evaluated using the Pairwise Associate Learning (PAL) task to assess learning and memory.

Dataset README information

README.md

Cholinergic-deficient-mouse-model: Brainstem cholinergic-deficient mouse model (VAChT^En1-Cre-flox/flox)

Male mice and their wild-type controls were evaluated at 7-10 months of age using the 5-Choice Serial Reaction Time (5-CSRT) task to assess attention. Immediately after (approximately at 9-12 months of age) these same mice were evaluated using the Extinction task to assess their ability to extinguish a response. A different cohort of male mice and their wild-type controls were evaluated at 11-13 months of age in the Pairwise visual discrimination (PVD) task to assess discrimination and reversal learning. Immediately after (still within 11-13 months of age) these same mice were evaluated using the Pairwise Associate Learning (PAL) task to assess learning and memory.

COMMON METADATA:

Dataset type: Cognitive Behavioral Data from Touchscreen Technology

Source: https://mousebytes.ca

DOI: https://doi.org/10.1096/fj.201802108R

Animal Specie: Mouse

Animal Sex: Male

Animal age (month): "7-10" for 5-choice task, "11-13" for PAL, PVD, and extinction tasks

Animal strain: VAChT^En1-Cre-flox/flox

Animal Genotype: VAChT^En1-Cre-flox/flox, VAChT^flox/flox

Housing: Single-housed

Light Cycle: Diurnal light cycle

Intervention: N/A

AGGREGATED DATA:

File Name:OK_En1CreVAChTfx_5C.csv

PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)

Data Link: https://mousebytes.ca/data-link?linkguid=cbd657dd-3d52-4a31-b35b-b9431fc288b9

Cognitive Task: 5_Choice

Aggregation Function: Mean

Trial by Trial: No

File Name:OK_En1CreVAChTfx_PVD.csv

PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)

Data Link: https://mousebytes.ca/data-link?linkguid=c0127e82-6ddb-4cb6-925e-dd74f7530394

Cognitive Task: Pairwise Visual Discrimination (PVD)

Aggregation Function: Mean

Trial by Trial: No

File Name:OK_En1CreVAChTfx_PAL_acquisition.csv

PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)

Data Link: https://mousebytes.ca/data-link?linkguid=37543e5e-0a83-413d-a6e3-2fe15bd4950d

Cognitive Task: Paired-Associates Learning (PAL), Acquisition

Aggregation Function: Mean

Trial by Trial: No

File Name:OK_En1CreVAChTfx_PAL_analysis.csv

PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)

Data Link: https://mousebytes.ca/data-link?linkguid=82ea3267-92dd-40d0-bb14-8f04dc1f2f55

Cognitive Task: Paired-Associates Learning (PAL), Analysis

Aggregation Function: Mean

Trial by Trial: No

File Name:OK_En1CreVAChTfx_Extinction_training.csv

PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)

Data Link: https://mousebytes.ca/data-link?linkguid=be379ef0-78a0-4839-b08c-7a143e180ed4

Cognitive Task: Extinction, Training

Aggregation Function: Mean

Trial by Trial: No

File Name:OK_En1CreVAChTfx_Extinction_probe.csv

PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)

Data Link: https://mousebytes.ca/data-link?linkguid=ffed86b9-87c4-4b19-a737-19e01d1fb644

Cognitive Task: Extinction, Probe

Aggregation Function: Mean

Trial by Trial: No

TRIAL BY TRIAL DATA:

File Name: OK_En1CreVAChTfx_5C_Trial.csv

PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)

Data Link: https://mousebytes.ca/data-link?linkguid=7b6798f6-422e-4e0f-a3fc-eb798414d89c

Cognitive Task: 5_Choice

Aggregation Function: N/A

Trial by Trial: Yes

File Name: OK_En1CreVAChTfx_PD_Trial.csv

PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)

Data Link: https://mousebytes.ca/data-link?linkguid=6ee1b933-e724-4d98-9229-1b231596d210

Cognitive Task: Pairwise Visual Discrimination (PVD)

Aggregation Function: N/A

Trial by Trial: Yes

File Name: OK_En1CreVAChTfx_PAL_acquisition_Trial.csv

PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)

Data Link: https://mousebytes.ca/data-link?linkguid=e03fd89c-9956-4290-9b98-ffe7272afdd4

Cognitive Task: Paired-Associates Learning (PAL), Acquisition

Aggregation Function: N/A

Trial by Trial: Yes

File Name: OK_En1CreVAChTfx_Extinction_training_Trial.csv

PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)

Data Link: https://mousebytes.ca/data-link?linkguid=25ece7a3-f192-454b-b95a-02e3162fd8a9

Cognitive Task: Extinction, Training

Aggregation Function: N/A

Trial by Trial: Yes

File Name: OK_En1CreVAChTfx_Extinction_probe_Trial.csv

PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)

Data Link: https://mousebytes.ca/data-link?linkguid=58127af1-b693-4bd5-b0ed-f15c8cfd08ae

Cognitive Task: Extinction, Probe

Aggregation Function: N/A

Trial by Trial: Yes

Download Using DataLad

CircleCI status

The following instructions require a basic understanding of UNIX/LINUX command lines. A subset of open datasets on the Portal are also available through a browser-based download button. The instructions below regard dataset download with the use of DataLad. To install DataLad on your system, please refer to the install section of the DataLad Handbook .

Note: For maximum compatibility with conp-dataset, the CONP recommends versions 3.12+ of Python, 10.20241202+ of git-annex, and 1.1.4+ of datalad.

1) Initiate the CONP dataset

Run the following command in the directory where you want the CONP dataset (conp-dataset) to be installed:

2) Install the mousebytes/MB-Cholinergic-deficient-mouse-model dataset

To install the mousebytes/MB-Cholinergic-deficient-mouse-model dataset, run the following commands to move into the "projects" subdirectory under the "conp-dataset" directory (created in the previous step) and run datalad install:

3) Download data from the mousebytes/MB-Cholinergic-deficient-mouse-model dataset

Now that the dataset has been installed, go into the mousebytes/MB-Cholinergic-deficient-mouse-model dataset directory.

The files visible after installing the dataset but before downloading (in the next step) are symbolic links and need to be downloaded manually using the datalad get command:

If you run datalad get * command, all the files available in the dataset directory will be downloaded.


For more information on how DataLad works, please visit the DataLad Handbook documentation.