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Integrated Biological Markers for the Prediction of Treatment Response in Depression: Data Release from the foundational study of the Canadian Biomarker Integration Network in Depression (CAN-BIND-01)
Creators: Ontario Brain Institute
Contact: Brain-CODE, datarelease@braincode.ca
Licenses: Refer to Brain-CODE Governance Policy
Version: 2.0
Size: 159.6 GB
No of Files: 14990
No of Subjects: 309
Primary Publication: Discovering biomarkers for antidepressant response: protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort. Raymond W. Lam et al. BMC Psychiatry. https://doi.org/10.1186/s12888-016-0785-x
Metadata file: DATS.json
Is About: Homo sapiens
Acknowledges: Ontario Brain Institute, Canadian Institute of Health Research, Government of Ontario
Spatial Coverage: Canada
Other Dates: Start Date: 2013-06-03 00:00:00 -- End Date: 2018-12-31 00:00:00
Description:
The Canadian Biomarker Integration Network in Depression (CAN-BIND) is a national program of research and learning. From 2013 to 2017, data were collected from 211 participants with major depressive disorder and 112 healthy individuals. The objective of this data-set is to integrate detailed clinical, imaging, and molecular data to predict outcome for patients experiencing a Major Depressive Episode (MDE) and receiving pharmacotherapy reflective of standard practice. The clinical characterization consists of symptom assessment, behavioural dimensions, and environmental factors. The neuroimaging data consist of structural, resting and task-based functional, and diffusion-weighted MRI images, as well as scalp-recorded EEG data. The molecular data currently consist of DNA methylation, inflammatory markers and urine metabolites. Baseline and Phase 1 (Weeks 2-8) data are now available for request.

Dataset README information

README.md

Integrated Biological Markers for the Prediction of Treatment Response in Depression

Dr. Sidney Kennedy, Dr. Pierre Blier, Dr. Faranak Farzan, Dr. Benicio Frey, Dr. Jane Foster, Dr. Raymond Lam, Dr. Glenda MacQueen, Dr. Roumen Milev, Dr. Daniel Mueller, Dr. Sagar Parikh, Dr. Susan Rotzinger, Dr. Stephen Strother, Dr. Claudio Soares, Dr. Valerie Taylor, Dr. Gustavo Turecki, Dr. Rudolf Uher, and the CAN-BIND Study Team

Overview

The Canadian Biomarker Integration Network in Depression (CAN-BIND) is a national program of research and learning. From 2013 to 2017, data were collected from 211 participants with major depressive disorder and 112 healthy individuals. The objective of this data-set is to integrate detailed clinical, imaging, and molecular data to predict outcome for patients experiencing a Major Depressive Episode (MDE) and receiving pharmacotherapy reflective of standard practice. The clinical characterization consists of symptom assessment, behavioural dimensions, and environmental factors. The neuroimaging data consist of structural, resting and task-based functional, and diffusion-weighted MRI images, as well as scalp-recorded EEG data. The molecular data consist of DNA methylation, inflammatory markers and urine metabolites. Baseline and Phase 1 (Weeks 2-8) data are now available for request.

Data organization

Data is organized into packages by Treatment Group (Control vs Major Depressive Disorder), Timepoint Imaging Scan Type, Molecular Data Type, and Clinical Data Collection Domain.

Access information

To gain access to Brain-CODE Controlled Data Release data, Study Investigators will submit requests via Data Release Portals at www.braincode.ca. These requests will be reviewed by the Brain-CODE Data Access Committee and the Brain-CODE Steering Committee. Learn more about these Committees in the Brain-CODE Governance Policy (https://braininstitute.ca/docs/Brain-CODE-Governance-Policy-version-FINAL.pdf).

Visit the Brain-CODE Knowledge Base to learn more about our data releases.

Citation

Lam, R.W., Milev, R., Rotzinger, S. et al. Discovering biomarkers for antidepressant response: protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort. BMC Psychiatry 16, 105 (2016). https://doi.org/10.1186/s12888-016-0785-x